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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

71 Study Matches

Brain Health Registry and Biospecimen Repository

The Brain Health Registry and Biospecimen Repository will create a research framework aiming to help us understand the causes of memory loss in Alzheimer's disease and other neurodegenerative disorders. We would like to recruit research participants 45+ years and up without any memory complaints, participants subjectively reporting memory complaints, and participants suffering from mild cognitive impairment or dementia symptoms due to neurodegenerative diseases. We will ask study participants about their medical history, their demographics, their social determinants of health, do a sleep quality assessment, and do neuropsychometric assessments. We will also create a biospecimen repository of blood, tissue and cerebral spinal fluid samples from the above participants.

Principal Investigator: Dongming Cai
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00022518
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Inclusion Criteria:
Ages 45+
Conditions: Brain & Nervous System
Keywords: Alzheimer's Disease, Clinics and Surgery Center (CSC), cognitive decline, dementia, memory issues, neurodegeneration, 45+
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Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

We will enroll healthy pregnant women (following enrollment, all subsequent study procedures will be completed postpartum) or postpartum women on hormonal birth control or no hormonal birth control with either a recent history of smoking and a desire to remain abstinent after childbirth, or who are currently smoking and motivated to quit smoking. Participants will be recruited throughout the continental United States (US). Participants living in Minnesota (our clinical site) will receive a 12-week course of exogenous progesterone. Participants will be followed for six months with remote visits, self-administered surveys, and self-collection of dried blood spots to measure hormones and smoking-related biomarkers.

Principal Investigator: Sharon Allen, PhD
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00020047
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Inclusion Criteria:

• 18 to 45 years old
• uncomplicated pregnancy at gestational week 30 or beyond, or birth of a child within the past 6 months
• history of ≥ 4 cigarettes per month during the six months prior to pregnancy
• motivation to become and/or stop smoking after delivery
• willing to use birth control for the 12 weeks of the study
• live in the continental US and have a device to connect to the internet for participation
• see link to clinicaltrials.gov for complete inclusion criteria
Exclusion Criteria:

• current daily use of nicotine replacement therapy or smoking cessation medications, with the exception of e-cigarettes
• major depressive disorder
• current or within the past 3 months treatment for drug or alcohol use
• see link to clinicaltrials.gov for complete exclusion criteria
Conditions: Cancer, Community Health
Keywords: post partum, smoking
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Lifestyle Counseling and Medication for Adolescent Weight Management (QUEST)

This study will compare the effectiveness and durability of intensive behavioral counseling vs. medical management plus low-intensity behavioral counseling on BMI, body fat, cardiometabolic risk factors, and quality of life in adolescents with severe obesity. We hypothesize that Wegovy (semaglutide) plus low-intensity behavioral counseling will elicit superior reductions in BMI and body fat and greater improvement in cardiometabolic factors and quality of life compared to intensive behavioral counseling at 56 weeks.

Principal Investigator: Aaron Kelly
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: STUDY00012932
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Inclusion Criteria:

• ages 12-17
• BMI greater than or equal to the 95th percentile for age and sex
Exclusion Criteria:

• Type 1 or Type 2 diabetes
• use of medications for obesity in the past 6 months
• any treatment with growth hormone
• bariatric surgery -major mental health diagnosis (study staff will review)
• pregnant or plan to become pregnant
• significant medical diagnosis (study staff will review)
Conditions: Diabetes & Endocrine, Children's Health
Keywords: Obesity, Overweight, weight loss
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Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function

This study is being done to learn more about the influence of the menopausal transition on autonomic and vascular function in midlife females. Participants will have their vitals taken and height, weight and waist-to-hip ratio measurements done, complete questionnaires, have blood draws, electrical activity of a nerve in leg measured (optional), have blood vessel function measured, breathing exercises, and a cold pressor test (putting a hand in ice-cold water).

Principal Investigator: Manda Keller-Ross
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00022683
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Inclusion Criteria:

• premenopausal women
• age 45-55 yrs
Exclusion Criteria:

• used nicotine or tobacco in the past six months
• pregnant or breastfeeding
• BMI ≥ 40 kg/m^2
• using hormonal contraceptives
• diagnoses of diabetes, carotid stenosis, hypertension, and/or sleep apnea
Conditions: Heart & Vascular, Women's Health
Keywords: Menopause transition, blood pressure, cardiovascular
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Global Registry For Novel Therapies In Rare Bone & Endocrine Conditions (Le-Na)

This research study is for creating a registry of all ages with conditions in endocrine and both health. Registries are used very often these days by doctors and scientists to collect information and use to perform research into rare conditions. This registry will be part of a global registry, called "GloBE-Reg" with the University of Glasgow (Scotland) and with the University of MInnesota.

Principal Investigator: Brad Miller, MD, PhD
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: STUDY00022139
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Inclusion Criteria:

• for this study is not for any specific diagnosis
• any child receiving human growth hormone treatment
Exclusion Criteria:
Unable to meet the Inclusion Criteria above.
Conditions: Rare Diseases, Children's Health
Keywords: growth hormone
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Biomechanical Mechanisms of Soft Tissue Deformation during the Volleyball Spike

No current studies have examined in vivo glenohumeral kinematics during the overhead volleyball spike despite the high prevalence of spike-related shoulder pain. The extreme shoulder positions achieved by volleyball players during the spike motion may contribute to unique deformations that could result in structural change or pathology of the rotator cuff and long head biceps tendons. The purpose of this study is to determine the extent to which GH kinematics differ between SAB and a simulated volleyball spike at a self-selected position of ball contact.

Principal Investigator: Paula Ludewig
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00015763
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Inclusion Criteria:

• 18 to 35 years old
• played at least 2 years of high school varsity-level volleyball and/or play competitive volleyball at the club level or NCAA D3/NAIA level or above
• have no shoulder pain that has resulted in removal from, or cessation of volleyball participation in the past 6 months
• have a negative clinical screening exam
• fluent in English
Exclusion Criteria:

• any injuries, impairments, or pain of the hitting arm that limits participation in volleyball
• shoulder pain related to the cervical spine
• history of trauma and/or surgery of the hitting shoulder
• currently pregnant.
Conditions: Bone, Joint & Muscle
Keywords: Volleyball, athlete, shoulder, spike mechanics
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Gender Identity Measurement In Early School Aged Children

The goal of this study is to learn more about how children (ages 5-8 years) describe their gender identities. We are also interested in learning more about the ways children think and develop. We will be giving children several tasks designed as games to assess flexibility in thinking, creativity, and the ability to take another person’s perspective.

Principal Investigator: G. Nic Rider
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: STUDY00015734
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Inclusion Criteria:

• Ages 5 to 8
• English speaking
Exclusion Criteria:

• unable to speak English
Conditions: Children's Health, Community Health
Keywords: child, creativity, gender, transgender
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Listening effort in people with hearing impairment

The purpose of this research is to understand the effort needed to understand speech if hearing is impaired. Listening effort is higher in people with hearing impairment and has wide-ranging negative consequences across many aspects of a person’s life. The goal of this project is to explore factors that make listening effortful, with special focus on the need to repair perceptual mistakes by relying on context.

Principal Investigator: Matthew Winn
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00004150
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Inclusion Criteria:

• There are two categories of participants: either people with cochlear implant (one or two cochlear implants) or people with normal hearing in both ears.
Exclusion Criteria:

• non native English speakers
Conditions: Ear, Nose & Throat
Keywords: cochlear implant, hearing loss, listening
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Health's Early Roots & Origins (HERO) Study

The way our bodies react to stress when we’re very young can affect our health for the rest of our lives – and this can vary from person to person. The goal of this research project is to learn more about how different children respond to stress and how to best measure stress in children. We are collecting a measure of attention skills and small samples of hair, cheek swabs, and saliva from children in all kinds of communities across the country. Scientists will look at these samples to learn more about how children respond to stress. This study session will last approximately 25-30 minutes.

Principal Investigator: Megan Gunnar
This study is also accepting healthy volunteers
IRB Number: STUDY00022119
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Inclusion Criteria:

• children 4 months to 5 years old
• speak English or Spanish
Conditions: Children's Health, Prevention & Wellness
Keywords: D2D
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A Phase 1/2a Open-Label Dose-Ranging and Observer-Blind Placebo-Controlled, Safety and Immunogenicity Study of mRNA-1647 Cytomegalovirus Vaccine in Female and Male Participants 9 to 15 Years of Age; mRNA-1647-P104

This study it to test an investigational vaccine called mRNA-1647 that is being developed for preventing cytomegalovirus (CMV) infection in people. CMV is a common virus that can spread easily through an infected person’s saliva or other body fluids such as blood, urine, and breast milk. We want see if the trial vaccine can prevent CMV infection in participants who have not been previously infected, to understand the safety (how many side effects you may have) of the trial vaccine, and to see if the trial vaccine results in participants making antibodies to CMV.

Principal Investigator: Mark Schleiss
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: SITE00001871
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Inclusion Criteria:

• female or male 9 to 15 years of age
• in good general health
• BMI requirements ( study staff will review)
• female participants of childbearing potential: negative pregnancy test and adequate contraception for at least 28 days prior to receiving vaccine through 3 months following vaccine administration
Exclusion Criteria:

• received, or plans to receive, any nonstudy vaccine less than 28 days prior to or after any study medication
• any diagnosis or condition requiring significant changes in management or medication within the 2 months before starting the study
• contact study staff for review of additional exclusion criteria
Conditions: Children's Health, Infectious Diseases
Keywords: CMV, cytomegalovirus, vaccine
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See this study on ClinicalTrials.gov

Dynamic Effects in Peripheral Auditory Processing

The purpose of this study is to learn more about the origin of tinnitus (phantom sound) and how age and hearing loss affect the ability to hear simple and complex sounds, such as tones and speech, presented in isolation and in the presence of other competing sounds. Possible participants may have normal hearing or mild-to-moderate hearing loss. Participants will be seated in a sound-treated room and listen to sounds over headphones, insert earphones (earbuds), or via loudspeakers. The tasks involve making judgments about the sounds, such as discriminating which of two sounds appeared to fluctuate in intensity or reporting the words in a sentence.

Principal Investigator: Magdalena Wojtczak
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: 0910S73104
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Inclusion Criteria:

• Ages 18-30 yrs or 55-75 yrs
• Good overall health
• No hearing loss or mild to moderate hearing loss
Exclusion Criteria:

• Neurologic disorders
• Past head trauma
• Tinnitus
Conditions: Community Health, Ear, Nose & Throat, Prevention & Wellness
Keywords: speech in noisy backgrounds, hearing, Speech understanding
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Vestibular and Cortical Contributions to Transitions in Freezing of Gait and Parkinson's Disease

This study will examine the brain activation associated with the transition between movements in Parkinson’s disease, and if these changes are related to the development of problems with moving (like freezing of gait) and thinking. We will look at brain activity associated with the vestibular (inner ear) and cortical (surface of the brain) systems. People with Parkinson’s disease (especially people with freezing of gait) sometimes have difficulty initiating changes in movement types, such as going from standing to walking, turning, or switching between slow and fast repetitive movements. The difficulty in movement transitions may be associated with an overactive vestibular system (inner ear) or cortical system. In each experiment in this study, we expect about 20-25 participants with Parkinson’s disease and freezing of gait, 20-25 participants with Parkinson’s without freezing of gait, and 20-25 control participants

Principal Investigator: Sommer Huffmaster
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00022459
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Inclusion Criteria:

• age 21-80 years
• diagnosis of idiopathic PD with and without freezing gait
• able to walk independently without the use of an assistive device (e.g. cane) for 50 meters (about 160 feet)
• for HEALTHY OLDER ADULTS: 40-80 years old, able to walk independently without a cane or walker and able to perform complex activities of daily living independently
• for HEALTHY YOUNG ADULTS: 21-44 years and able to walk independently without a cane or walker
Exclusion Criteria:

• any musculoskeletal disorder that affects the ability to stand or walk
• history of musculoskeletal disorders that significantly affect movement of lower limbs
• uncorrected visual impairment
• history of visual and/or vestibular conditions
• moderate to severe hearing impairment
• women who are pregnant
• study staff will discuss additional exclusion criteria
Conditions: Brain & Nervous System
Keywords: Clinics and Surgery Center (CSC), freezing gait, Parkinson's disease
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See this study on ClinicalTrials.gov

The effects of cigarette smoking and alcohol on DNA damage in the oral cavity

The purpose of this study to examine the effects of cigarette smoking and drinking alcohol on the formation of DNA damage in the mouth. The overall goal is to identify DNA damage that may be important to the development of head and neck cancers.

Principal Investigator: Stephen Hecht, PhD
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00021212
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Inclusion Criteria:

• 21 years of age or older
• Smoke cigarettes daily
• Drink alcohol regularly
Exclusion Criteria:

• Use other tobacco/nicotine products
Conditions: Prevention & Wellness, Cancer
Keywords: alcohol, cigarettes, drinking, Smoking, tobacco
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Ten Thousand Families Study

The purpose of this study is to study the evolution of early life risk factors that may lead to cancer and other conditions. This is a prospective cohort study of families who reside in Minnesota.

Principal Investigator: Jen Poynter
Age Group: Not specified
This study is also accepting healthy volunteers
IRB Number: STUDY00000877
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Inclusion Criteria:

• 1st Participant: 18+ living in MN
• Other family members: All ages and must live in MN, ND, SD, IA, or WI
• Participants ages 0-17 must have a parent consent to their participation and assist with study activities
Exclusion Criteria:

• Unwilling or unable to provide DNA and blood sample
• Does not have at least 1 living family member in MN IA, ND, SD, or WI
Conditions: Cancer, Microbiota, Prevention & Wellness
Keywords: Minnesota, PFAS, environment, exposures, family, genetics, glyphosate, lifestyle, radon, 10KFS, D2D
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Neural Correlates of Goal Prioritization and Conscientiousness

This research will use neuroimaging to study the brain systems involved in prioritizing goals effectively, as well as testing whether variation in those systems is associated with the personality trait conscientiousness, which reflects organization, self-discipline, and industriousness and predicts important health and other life outcomes.

Principal Investigator: Colin DeYoung
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00019311
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Inclusion Criteria:

• age 20 - 50
• right handed
• no major psychiatric illness
Exclusion Criteria:

• claustrophobia
• any metal or devices in the body (e.g., pace makers, aneurysm clips etc.)
Conditions: Brain & Nervous System
Keywords: Brain imaging, Personality
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Pathogen Genomics Center of Excellence: Prospective Surveillance of Respiratory Pathogens and Antimicrobial Resistance in Diverse Regional Populations (MINNE-LOVE-2)

Respiratory illnesses, including ear and sinus infections, colds, and pneumonias, are among the most common infectious diseases affecting Minnesotans across their lifespan. These diseases can be caused by many different types of microbes—bacteria, viruses and fungi—and different types of microbes may require different kinds of treatment. This research is being done to learn more about the specific types of microbes that cause respiratory infections in children and adults across the state of Minnesota over time. Antimicrobial resistance happens when microbes develop the ability to defeat the drugs designed to kill them. Through this study, we will learn which types of genes are carried by microbes living in the respiratory tract by collecting and analyzing nasal and oral specimen.

Principal Investigator: Beth Thielen
Age Group: Not specified
This study is also accepting healthy volunteers
IRB Number: STUDY00019522
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Inclusion Criteria:

• age at least 18 years and able to provide informed consent AND willing and able to collect nasal swabs and complete symptom questionnaires with symptomatic respiratory illness Or
• age less than 18 years within the same household of at least 1 adult participant in study AND parent/guardian available to provide informed consent AND self or parent/guardian willing and able to collect nasal swabs and complete symptom questionnaires with symptomatic respiratory illness
Exclusion Criteria:

• presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the participant or the quality of the data (e.g., parent not able to answer the questionnaire because of a psychological condition or an anxiety disorder that is severe)
• routine mucosal specimen collection is not medically advised (such as severe immunocompromising condition, bleeding disorder)
Conditions: Community Health, Infectious Diseases, Respiratory System
Keywords: germs, infection, respiratory illness, RSV, virus
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Creativity Camp Study

This study explores how engaging in creative activities may be helpful for mental health and wellbeing in adolescents. Study participants will attend eight sessions (over two weeks) of Creativity Camp which involves a range of different kinds of arts activities. Participants will also complete a series of questionnaires, interviews, and other assessments to assess the potential benefits of the camp. We have previously shown that Creativity Camp is effective for reducing depression symptoms and improving well-being in adolescents with depression.

Principal Investigator: Kathryn Cullen
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: STUDY00014280
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Inclusion Criteria:

• ages 12-17
Exclusion Criteria:

• neurodevelopmental disorder (e.g. intellectual disability, severe autism)
• major medical and/or neurological illness
Conditions: Children's Health, Mental Health & Addiction
Keywords: Adolescents, Arts, Creativity
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Brain Training for Substance Use Disorders

Participants play games designed to train visual attention towards natural, non-drug-related scenarios. A biofeedback loop between gameplay and an electroencephalogram (EEG) system monitors game performance and guides game difficulty.

Principal Investigator: Justin Anker
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: SITE00001900
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Inclusion Criteria:

• 18 to 65 years of age
• admitted to Fairview's Lodging Plus program for chemical dependency treatment with opioid use being the primary reason
• able to read at a minimum of a 6th grade reading level
• willing to provide own contact information for follow-up visit(s)
• for HEALTHY CONTROLS: 18 to 65 years old, able to read at a minimum of a 6th grade reading level, and willing to provide own contact information for follow-up visit(s)
Exclusion Criteria:

• pregnancy
• history of serious neurological illness (e.g., Chronic seizure disorder, Wernicke-Korsakoff Syndrome, Epilepsy, Any history of seizures)
• unable to see text and photos clearly on a computer display
• current or previous problems using opioids, other prescription (prescribed or not prescribed) or illicit drugs
• regular nicotine user (e.g., cigarette smoker, e-cig user) within the past 12 months and
• unwillingness to change hairstyle (e.g., braids, pony tails, dreadlocks) or remove wig to accommodate application of the EEG headset, if necessary
Conditions: Brain & Nervous System, Mental Health & Addiction
Keywords: biofeedback, brain games, brain training, neurofeedback, noninvasive eeg, substance use, wearables
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Effects of relighting on smoke toxicant deliveries and subjective smoking measures

The purpose of this study is to understand how relighting cigarettes affects the level of toxicants inhaled during smoking, compared to smoking non-relit cigarettes.

Principal Investigator: Irina Stepanov
Age Group: 21 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00021107
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Inclusion Criteria:

• at least 21 years old
• smoking at least 5 cigarettes/day for at least 1 year
• engaging in relighting behavior – extinguishing, saving, and later relighting unfinished cigarette butts
• no attempts to quit smoking in the past month nor intentions to quit in the next month
• systolic blood pressure < 160, diastolic blood pressure < 100 and heart rate < 105 bpm
• see link to clinicaltrials.gov for complete inclusion and exclusion criteria
Exclusion Criteria:

• current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month
• women who are planning to become pregnant, pregnant or breastfeeding
Conditions: Cancer, Community Health
Keywords: Cigarette, Nicotine Dependence, Smoking, Tobacco

NEA Research Lab

This keystone study will invite adolescents into a 2-semester creative arts / science program, with arts activities taking place at the Masonic Institute of the Developing Brain (MIDB).

Principal Investigator: Kathryn Cullen
Age Group: Up to 18 years old
This study is also accepting healthy volunteers
IRB Number: STUDY00015930
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Inclusion Criteria:

• age 13-17
• adolescents and at least one parent / guardian must be able to speak English
Exclusion Criteria:

• unable to have a MRI (e.g. claustrophobia, braces)
• neurodevelopmental disorder (e.g. intellectual disability, severe autism)
• major medical and/or neurological illness
• pregnancy when starting the study
Conditions: Children's Health, Mental Health & Addiction
Keywords: Adolescents, Arts, Creativity
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Measurement of Upper Aerodigestive Tract Pressures During Phonation

The purpose of this pilot research study is to test whether a tool called “High-Resolution Manometry” can diagnose laryngeal dystonia (also known as spasmodic dysphonia) and measure how well treatment works. High-Resolution Manometry measures pressures from a small catheter that is passed from your nose into your throat. We believe that pressures in the throat might be different for people with laryngeal dystonia than for people without laryngeal dystonia, or with other types of voice disorders. If we can diagnose laryngeal dystonia shortly after symptoms start, we can get patients the treatment they need sooner.

Principal Investigator: Jesse Hoffmeister
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00015206
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Inclusion Criteria:
Patients with adductor laryngeal dystonia and:
• experienced improvement in voice quality following injection of botulinum toxin into the thyroarytenoid complex
• received their most-recent injection within 6 months
• age 18-80 years old
• able to read and write in English
• For Healthy Controls:
• age 18-80
• have no known voice problem
• able to read and write in English Patients with Muscle Tension Dysphonia:
• Age 18-80 (age-and sex matched to adductor laryngeal dystonia)
• Diagnosis of primary muscle tension dysphonia by a laryngologist and speech pathologist in the “...absence of current organic vocal fold pathology, [and] without obvious…neurologic etiology.”18
• Able to read and write in English
• Muscle tension dysphonia patients who either haven’t started voice therapy, or for whom symptoms persisted despite voice therapy
Exclusion Criteria:
For people with adductor laryngeal dystonia, Muscle Tension Dysphonia and healthy controls:
• diagnosis of vocal tremor, abductor laryngeal dystonia, any type of vocal fold lesion, or vocal fold paralysis
• known swallowing disorder (oropharyngeal or esophageal), with the exception of transient post-botulinum toxin injection-induced dysphagia
• pregnant
• prisoners
• allergy to topical anesthetic
• cannot fast for 6 hours (4 hour fast prior to study, up to 2 hours to complete the study)
• recent facial trauma
• recent nasal, pharyngeal, laryngeal, or esophageal surgery or obstruction
Conditions: Ear, Nose & Throat
Keywords: Clinics and Surgery Center (CSC)
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Vasomotor symptoms of menopause and cardiovascular disease: What is the link?

Study to examine the physiological responses that occur during a hot flush in postmenopausal women

Principal Investigator: Manda Keller-Ross
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00013742
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Inclusion Criteria:
Participants must have completed menopause and experience either no menopausal hot flashes or experience three menopausal hot flashes a day.
Exclusion Criteria:

• Reported nicotine/tobacco use within the last six months
• Diabetic or asthmatic
• Diagnosed significant carotid stenosis
• History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury
• Existing metabolic or endocrine abnormalities
• Use of heart/blood pressure medications that are determined to interfere with study outcomes
• Use of oral contraceptives (or other hormonal contraceptives, including intrauterine devices or contraceptive implants) and/or hormone therapy
• Pregnant or breastfeeding
• Unwilling or unable to refrain from consuming caffeine or alcohol in the 12 hours before visit two and three.
• Unwilling or unable to refrain from vigorous exercise (at least 10 minutes in duration) in the 12 hours before visit two or three
• Unwilling or unable to fast in the eight hours before visit two or three
• Body mass index ≥ 35 kg/m2
Conditions: Blood Disorders, Brain & Nervous System, Women's Health
Keywords: autonomic nervous system, Blood pressure, hot flashes, hypertension, menopause, night sweats
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Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)

The purpose of this research is to learn more about the immune function of patients who are critically ill and may or may not have sepsis through assessment of blood samples at the time of their illness. We will use the blood to determine whether the immune system is suppressed (slowed or stunted) and measure the amount of suppression. Our research team will compare blood from healthy participants to people who are critically ill to better understand immune system suppression.

Principal Investigator: Thomas Griffith
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: SITE00001746
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Inclusion Criteria:

• Adults age 45 and older
• Ability to obtain Informed Consent prior to blood collection.
Exclusion Criteria:

• Current, chronic steroid use
• Pregnancy
• Current or recent (within 7 days) use of antibiotics.
Conditions: Immune Diseases
Keywords: Sepsis
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Impact of a full-mouth electronic toothbrush on indicators of gingivitis and patient perceptions: A randomized clinical trial

The purpose of this trial is to investigate a full-mouth electronic toothbrush (FMET) and foam system compared to a conventional electronic toothbrush (ETB) and dentifrice during a 30-day period to evaluate the impact on clinical indicators of gingivitis, plaque, safety, and patient perceptions.

Principal Investigator: Michelle Arnett
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00022906
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Inclusion Criteria:

• diagnosis of mild to moderate gingivitis
• minimum of five natural teeth in each quarter of the mouth
• willing to stop all professional oral hygiene care
• willing to stop use of any other dental cleaning aids (dental floss, water flossers, interdental brushes, dental or tooth picks, mouthwash, etc.)
• access to personal email account and a device connected to the internet
Exclusion Criteria:

• aggressive, necrotizing, uncommon periodontal disease, or any uncontrolled periodontal condition
• unable to independently brush teeth
• fixed prosthesis (i.e. implant retained denture), orthodontic appliance or under orthodontic treatment
• pregnant, planning to become pregnant, or unsure of pregnancy status
• use of cigarettes within the last year
Conditions: Rare Diseases, Dentistry
Keywords: Feno Smartbrush, teeth, tooth brush, dental hygiene, gingivitis
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Online intervention on lung cancer screening among high-risk smokers: A pilot intervention study

Researchers from the University of Minnesota are looking for adult volunteers to participate in a lung cancer screening online educational intervention study.

Principal Investigator: Fang Lei
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00020835
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Inclusion Criteria:

• between 50 and 80 years old
• smoke or did smoke for a long time
• can read/understand English
Exclusion Criteria:

• diagnosed with lung cancer or other diseases which substantially impact participants’ life expectancy
Conditions: Cancer
Keywords: Smoking
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Registry Study of Childhood Cancer in Minnesota

The aim of this study is to obtain newborn blood spots (NBS) and tumor specimens for children and adolescents diagnosed with malignant neoplasms.

Principal Investigator: Erin Marcotte
Age Group: Not specified
This study is also accepting healthy volunteers
IRB Number: STUDY00018811
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Inclusion Criteria:

• 0 to 21 years of age
• child diagnosed with any type of tumor or cancer
• born in a state that banks newborn blood spots
• able to understand English or Spanish
• parents or siblings may also contribute specimens
Conditions: Cancer
Keywords: blood specimen, cancer, tumor
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The Lung Cell Study (TLC)

The purpose of our research study is to increase our understanding on the human lung immune response to infection. We aim to use this knowledge to develop novel approaches on the prevention and treatment of lung infections. To accomplish this, we plan to obtain cells from the airways and blood of healthy volunteers to perform immune experiments.

Principal Investigator: Monica Campo Patino
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00016947
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Inclusion Criteria:

• healthy volunteers without systemic or respiratory disease
• non-smokers or former smokers who quit more than 6 months ago (including marijuana)
• ages 18-50
• preferred but not required: have lived in countries in Africa, Latino America or South East Asia
• preferred but not required: history of positive tuberculosis (TB) skin or blood test
Exclusion Criteria:

• recent illness, bleeding disorders, or a history of heart, lung, or systemic disease
• weakened immune system or use of immunosuppressant medication
• use of inhaled substances in the past six months or history of heavy smoking
• allergy or prior adverse reaction to lidocaine, midazolam, or fentanyl
• pregnancy
Conditions: Immune Diseases, Infectious Diseases, Respiratory System
Keywords: blood, blood donation, blood draw, bronchoscopy, Healthy Volunteer, TB, TLC, Tuberculosis
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Assessments of sound perception and brain activation in response to paired sound and electrical stimulation of surface ear regions

We are investigating how paired non-invasive electrical stimulation of surface body regions and sound changes sound perception and tinnitus. Body stimulation regions include: external ear/behind the ear, shoulder, neck, forearm, hand, and upper arm. We aim to better understand the optimal conditions of this paired stimulation, which opens opportunities for applying this method to improving hearing loss or tinnitus. We are studying three groups of people: those with normal hearing, those with mild to moderate hearing loss, and those with tinnitus.

Principal Investigator: Hubert Lim
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00016992
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Inclusion Criteria:

• normal hearing or hearing loss with or without tinnitus
• not users of Cochlear Implant or hearing aids
Conditions: Ear, Nose & Throat
Keywords: hearing loss, tinnitus, auditory plasticity, neuromodulation, transcutaneous electrical stimulation
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Characterization of spleen motion and anatomy using imaging and sensors

This research is being performed to examine how the spleen moves during breathing in various body positions and breathing conditions. Physical measurements of the participant's body will be recorded (weight, height, and body dimensions) and then noninvasive recordings of the spleen and breathing patterns will be recorded. The spleen motion will be measured using standard abdominal ultrasound imaging, and breathing will be measured with accelerometers (small devices about the size of a quarter that measure the movement of the chest during breathing).

Principal Investigator: Hubert Lim
Age Group: 18 years and over
This study is also accepting healthy volunteers
IRB Number: STUDY00013252
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Inclusion Criteria:

• at least 18 years old
Exclusion Criteria:

• individuals who have had a splenectomy
• people with breathing difficulties and/or individuals for whom short breath holds and modification of breathing patterns is difficult or uncomfortable
• unable to maintain five body positions: sitting, sitting with a 45 degree recline, laying on back (supine), laying on right side, and laying face down (prone) comfortably and independently
• unable to speak and read English
Conditions: Digestive & Liver Health
Keywords: Imaging, Spleen
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Neural and Behavioral Markers of the Temporal Dynamics of Language Planning and Phonological Working Memory Processes in Persons Who Stutter

This is a study of persons who do and do not stutter between ages 7 and 65 years. This study is trying to figure out how attention skills influence memory, language, and speech fluency skills.

Principal Investigator: Jayanthi Sasisekaran
Age Group: Not specified
This study is also accepting healthy volunteers
IRB Number: STUDY00013042
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Inclusion Criteria:

• age 7 through 65 years
• remaining eligibility will be determined based on response to an intake survey
Conditions: Children's Health, Community Health
Keywords: adults, attention, fluency, language, memory, speech production, Stuttering, children
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