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Search Results Within Category "Dermatology (Skin, Hair & Nails)"

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11 Study Matches

A Phase 1b/2, Double-Blind, Placebo-Controlled, Randomized, Parallel-Arm Study to Explore the Safety, Pharmacokinetics, and Proof of Biological Activity of DS-7011a in Patients with Systemic Lupus Erythematosus and Active Cutaneous Lupus Erythematosus

The main purpose of this study is to gather information about DS-7011a, an investigational drug that may help to treat systemic lupus erythematosus (SLE), including cutaneous lupus erythematosus (CLE). Overall study duration for a participant is expected to be approximately 28 weeks.

David Pearson
18 years and over
This study is NOT accepting healthy volunteers
SITE00002046
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Inclusion Criteria:

• Diagnosed with Lupus at least 6 months ago
• active CLE (acute, subacute, and chronic cutaneous lupus), with active skin involvement
• Body mass index (BMI) at least 18 kg/m and body weight at least 45 kg (99lbs.)
• see link to clinicaltrials.gov for complete inclusion and exclusion criteria
Exclusion Criteria:

• history of cancer in the past 2 years
• history of chronic, recurrent (3 or more of the same type of infection in 1 year) or recent serious infection including HIV, viral hepatitis, or shingles
Dermatology (Skin, Hair & Nails)
CLE, Lupus, SLE, Systemic Lupus Erythematosus
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Protocol M23-716: A Phase 3 randomized, placebo-controlled, double-blind program to evaluate efficacy and safety of upadacitinib in adult and adolescent subjects with severe alopecia areata

This study will assess how effective and safe the use of the medication named Upadacitinib is for the treatment of signs and symptoms of severe hair loss in adults.

Maria Hordinsky
This study is NOT accepting healthy volunteers
STUDY00021415
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Inclusion Criteria:

• 12-63 years of age
• have more than 50% hair loss
Exclusion Criteria:

• pregnancy
Dermatology (Skin, Hair & Nails)
Alopecia Areata
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A 6-Month Phase 3, Multicenter, Prospective, Randomized, Double-Blind, Vehicle-Controlled Study, to Evaluate the Efficacy and Safety of Topically Applied Clascoterone (Cortexolone 17A-Propionate) Solution for the Treatment of Androgenetic Alopecia in Males, Followed by a 6-Month Single-Blind Treatment with Clascoterone or Vehicle BID Solution. (SCALP 1) (SCALP1)

We are studying a new topical drug, Clascoternone, to treat adult males who have male pattern baldness. Participants randomly (by chance) receive the drug or an inactive solution that is applied to the area of hair loss twice a day for six months. We will compare the effectiveness and side effects of the two groups. Men who have regrowth of hair may also participate in a second six-month treatment to look at the long-term effectiveness of the drug.

Maria Hordinsky
18 years and over
This study is NOT accepting healthy volunteers
SITE00002038
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Inclusion Criteria:

• men who are 18 or older
• have mild to moderate Androgenic Alopecia (AGA) in temple and top region of the scalp
• willing to maintain the same hairstyle, hair length and hair color throughout the study
• agree to continue shampoo frequency and other general hair care products and regimen for the entire study
• agree to maintain same dietary and supplement pattern
Exclusion Criteria:

• any dermatological disorders at the temple or the top of the scalp
• current or recent history (within 6 months) of hair weaves, non-breathable wigs, or hair bonding -scalp hair transplants at any time
• see link to clinicaltrials.gov for additional exclusion criteria (study staff will review)
Dermatology (Skin, Hair & Nails)
Clinics and Surgery Center (CSC), Alopecia, Androgenetic Alopecia, Male Alopecia, AGA
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Neptunia A Phase IIa, Randomized, Parallel, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Enpatoran in Dermatomyositis and Polymyositis Participants receiving Standard of Care

Dermatomyositis (DM) and Polymyositis (PM) are both autoimmune diseases. In autoimmune diseases, the body’s immune system, which normally protects us against infection and illness, starts to attack the body’s own cells instead. The main purpose of this research study is to see whether an investigational drug called enpatoran (referred to as the “study drug”) works better than placebo to improve symptoms in people with DM or PM. A “placebo” looks like the study drug but does not have any active substance in it. Researchers also hope to find out more about how safe the study drug is and how well tolerated it is.

David Pearson
18 years and over
This study is NOT accepting healthy volunteers
SITE00001761
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Inclusion Criteria:

• adults with primarily diagnosed with Dermatomyositis (DM) or Polymyositis (PM)
Exclusion Criteria:

• diagnosis of myositis within 3 years of cancer
• malignancy-associated or juvenile DM
Dermatology (Skin, Hair & Nails)
Dermatomyositis (DM), Polymyositis (PM)
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A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Efficacy and Safety Study of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

We are studying a new drug, INCB054707, used to treat people who have hidradenitis suppurativa which is a chronic skin condition characterized by lumps or boils in places such as the armpits or groin. The skin lesions develop because of inflammation of the follicle. We are studying two doses of the drug and we will compare the effectiveness and side effects that occur. We will also have a group that receives an inactive medication (placebo). After the first 12 weeks of taking the drug or placebo, all participants will receive the active drug. The study will last for about 62 weeks.

Noah Goldfarb
18 years and over
This study is NOT accepting healthy volunteers
SITE00001790
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Inclusion Criteria:

• moderate to severe H.S. for at least 3 months
Exclusion Criteria:

• mild H.S.
• women who are pregnant (or who are considering pregnancy) or breastfeeding
Dermatology (Skin, Hair & Nails), Rare Diseases
Hidradenitis Suppurativa( HS)
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A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Baricitinib in Children from 6 Years& Less than 18 Years of Age with Alopecia Areata

We are conducting a research study for children ages 6-17 with patchy Alopecia Areata (AA). The purpose of this research study is to learn more about the safety, tolerability and efficacy of an investigational drug called Baricitinib. This study will compare the investigational drug to a placebo (inactive substance) to see how well the investigational drug works.

Maria Hordinsky
Up to 18 years old
This study is NOT accepting healthy volunteers
SITE00001967
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Inclusion Criteria:

• children 6 to 18 years old
• at or above the 5th percentile of weight for age
• diagnosis of Alopecia Areata (AA) for at least 1 year
• current AA episode of at least 6 months duration with hair loss encompassing 50% or more of the scalp
• history of trial and failure with at least 1 available treatment
• history of psychological counseling related to AA
Exclusion Criteria:

• primarily diffuse type of AA (characterized by diffuse hair shedding)
• currently experiencing other forms of alopecia including, but not limited to: trichotillomania, TE, chemotherapy-induced hair loss, or any other concomitant conditions (for example, tinea capitis, psoriasis, lupus erythematosus, or secondary syphilis)
Dermatology (Skin, Hair & Nails)
AA, Alopecia Areata, hair loss
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A Parallel Group Treatment, Phase 2a, Double-blind, Two-arm Study to Investigate the Efficacy and Safety of Farudodstat Tablets Compared with its Placebo in Male or Female AlopeciaAreata Participants Aged 18 Years and Older with 50% or Greater Scalp Hair Loss (FAST-AA)

The main purpose of the study is to see whether farudodstat, taken orally for 12 weeks, can help people with alopecia areata and to find out if farudodstat is safe and tolerable when compared to placebo. The placebo is a pill that looks like farudodstat tablet but has no drug or other active ingredient in it.

Maria Hordinsky
18 years and over
This study is NOT accepting healthy volunteers
SITE00001917
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Inclusion Criteria:

• at least 18 years old
• weight at least 40 kg (88 lbs)
• severe or very severe Alopecia Areata (AA)
• contact study staff for additional criteria for AA
Exclusion Criteria:

• history of androgenic alopecia or female pattern hair loss prior to AA or other types of hair loss
• history or presence of hair transplants
• other scalp disease that may impact AA assessment or require topical treatment (including, but not limited to scalp psoriasis, seborrheic dermatitis, actinic keratosis)
Dermatology (Skin, Hair & Nails)
Alopecia Areata, Hair loss
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A Phase 1/2A, (Part B, participant-, investigator-, and sponsor-blind) study; to investigate the safety, pharmacokinetics, and efficacy (Part B only) of UCB1381 in study participants with moderate to severe atopic dermatitis;(Part B)

This is an early study of a new drug called UCB1381. In the first part of the study, we are looking at increasing doses of the drug when compared to an inactive drug (placebo) when given to healthy participants. In the second part, we will look at the safety and effectiveness of one dose of UCB1381 compared to an inactive drug (placebo) when given to people who have moderate to severe Atopic Dermatitis.

Paul Bigliardi
18 years and over
This study is NOT accepting healthy volunteers
SITE00001885
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Inclusion Criteria:

• 18-65 years of age
• moderate to severe itch
Exclusion Criteria:

• diabetes not well controlled with diet
• history of Crohns disease or Colitis
Dermatology (Skin, Hair & Nails)
Atopic Dermatitis
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A Phase 1b, Randomized, Vehicle-Controlled, Double-Blind, Pharmacokinetics, Pharmacodynamics, and Safety Study of ARQ-255 Topical Suspension in Healthy Volunteers and Subjects with Alopecia Areata

This study is being done to evaluate the safety and tolerability of twice daily application of the study drug, ARQ-255 topical suspension 3% people with alopecia areata. There are 2 study drugs in this study: ARQ-255 topical suspension 3% and vehicle (placebo). Participants will be randomized (like drawing straws) to either ARQ-255 topical suspension 3% or vehicle to be applied twice daily for 12 weeks. A vehicle is a study treatment that looks like the test drug and is made from the same base products used to make ARQ-255 topical suspension 3%, but it does not contain any active study ingredients.

Maria Hordinsky
18 years and over
This study is NOT accepting healthy volunteers
SITE00001818
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Inclusion Criteria:

• 18 to 70 years of age
• have alopecia areata
• able to apply topical study medication
Exclusion Criteria:

• alopecia totalis
• alopecia universalis
Dermatology (Skin, Hair & Nails)
alopecia areata
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Use of Continuous Wave Doppler to assess Vascular Malformations in Pediatric Dermatology

The aim of our study is to look at blood flow in various tumors and irregularities located in blood vessels using a handheld continuous wave doppler. Correct and efficient diagnosis of vascular anomalies (outside of what is expected to happen in blood vessels) in pediatric patients will help determine a treatment plan. Blood flow in vascular anomalies has not been well described in the past.

Sheilagh Maguiness
Not specified
This study is NOT accepting healthy volunteers
STUDY00012200
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Inclusion Criteria:

• less than 21 years old
• have a vascular anomaly such as Arteriovenous malformations (AVM), Capillary malformations (CM), Venous malformations (VM), Lymphatic malformations (LM), Pyogenic granuloma (PG), Infantile hemangioma (IH), or Congenital hemangioma (CH)
• being treated at University of MN pediatric dermatology outpatient clinic or the multidisciplinary vascular anomalies clinic
Exclusion Criteria:

• history of any prior surgical, radiologic, medications for treatment (including oral or topical beta blocking agents)
Dermatology (Skin, Hair & Nails)
Vascular Anomalies
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An Open Label Study to Evaluate DPCP Ointment for the Treatment of Alopecia Areata

The purpose of the study is two-fold. First, we will see whether treating alopecia areata with a ointment containing DPCP is safe and causes hair to regrow. Second, we will take blood and scalp biopsy samples and analyze them for biomarkers. The biomarkers in this study are molecules related to DNA that tell us whether certain genes are turned on or off. Those markers may help us predict whether or not patients respond to this type of treatment. The testing for biomarkers will also help us to better understand what causes alopecia areata. This study requires you to make forty-two (42) visits to the study site over a course of approximately four (4) months.

Maria Hordinsky
18 years and over
This study is NOT accepting healthy volunteers
1407M52002
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Inclusion Criteria:

• diagnosis of extensive alopecia areata
• women of childbearing age must agree to use an acceptable, highly effective method of birth control to prevent pregnancy
Exclusion Criteria:

• women who are pregnant or breast feeding
• current controlled or uncontrolled infection of any type
• systemic therapy for cancer within the past five years except for adequately treated Squamous Cell Carcinoma (SCC) or Basal Cell Carcinoma (BCC) of the skin
• additional medical conditions, treatments for alopecia areata, or mental health diagnosis (study staff will review)
Dermatology (Skin, Hair & Nails)
Alopecia Areata
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See this study on ClinicalTrials.gov