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Intravenous Subanesthetic Repeated Dose of Ketamine in Treatment Resistant Depression: A Pilot Study

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The overall objective of this proposal is to determine the efficacy of a single vs. multiple sub-anesthetic IV ketamine infusions for patients with TRD. We plan to conduct a randomized controlled trial (RCT) comparing a single ketamine infusion preceded by 5 midazolam infusions vs. six ketamine infusions.

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This study is NOT accepting healthy volunteers

Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant

Paulo Shiroma - paulo.shiroma@va.gov
Kelvin Lim
Phase II
1306M36501
NCT02360280
See this study on ClinicalTrials.gov

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