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Microbiome and Immunosuppression: The Mission Study

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18 Years and over
This study is NOT accepting healthy volunteers
Inclusion Criteria:

• 1) Participants undergoing kidney transplant 2) Male or female at least 18 years of age at time of enrollment 3) Will or have received a living or deceased donor kidney transplant 4) Planned post-transplant immunosuppression regimen of mycophenolate mofetil dosed every 12 hours (Cellcept or generic) and immediate release tacrolimus dosed twice daily with trough concentration monitoring (generic or brand formulation). 5) Able and willing to complete study-related procedures and visits 6) Signs written informed consent
Exclusion Criteria:

• 1) Recipient of a previous non-kidney transplant 2) Subject is a multi-organ transplant recipient 3) Presence of active gastroparesis and documented in medical record 4) Liver dysfunction (total bilirubin >2x upper limit of normal) within 2 months of enrollment 5) Patients that take medications that significantly inhibit UGT enzymes. 6) Patients that take medications that significantly inhibit or induce the biliary transporters 7) Patient is known to be HIV positive 8) Pregnant or nursing (lactating) women 9) Non-English speaking 10) Patients who have undergone bariatric surgery

Other: collection of body microbioma

Kidney Transplant Rejection, Kidney Transplant

transplant, kidney, Microbiome

Pamala Jacobson, PharmD, FCCP - jacob117@umn.edu
NCT04953715
See this study on ClinicalTrials.gov

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