SKOAP: A Sequenced-Strategy for Improving Outcomes in people with knee OsteoArthritis Pain


There is an urgent public health need to reduce our reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA). This effectiveness trial will compare recommended treatments to reduce pain and functional limitations in KOA and identify clinical and patient-level factors associated with treatment response. These results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-opioid alternatives.

I'm interested

Male or Female
18 years and over
This study is NOT accepting healthy volunteers
Inclusion Criteria:

• have osteoarthritis of a knee(s)
Exclusion Criteria:

• scheduled knee replacement surgery or history of knee replacement in the painful knee
• medical condition that prevents exercise
• untreated bleeding disorder
• ulcers or an open wound near the knee

Other: Best Practices, Drug: Duloxetine, Combination Product: Intra-Articular Injection, Procedure: Nerve Procedure with long acting blocks, Procedure: Nerve Procedure with nerve ablation, Behavioral: Pain Coping Skills Training

Arthritis & Rheumatic Diseases

arthritis, knee pain, osteoarthritis

Alicia Bulleri -
Clarence Shannon
Phase 3
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