Use of 31P MRS to Assess the Effect of Nicotinamide Riboside on Brain NAD+ in Athletes with Football-Related Concussion


This study is being conducted at Mayo Clinic; the University of Minnesota site is responsible for the MRI portion of the study.

I'm interested

18 Years and over
This study is also accepting healthy volunteers
Inclusion Criteria:

• Adult current and former (within 2 years) collegiate athletes (football, rugby, soccer, hockey, and volleyball)
• Body mass index (estimated based on height and weight) from 23 to 37
• Willing to provide informed consent, ingest test substance, and provide blood specimens
• Willing to comply with study instructions and maintain current level of physical activity throughout the study
Exclusion Criteria:

• History of loss of consciousness of more than 5 minutes
• Contraindications to Magnetic Resonance Imaging (MRI), such as implanted medical devices, metal objects, or pacemakers
• History of epilepsy
• History of more than 3 concussions
• History of headache preceding a concussion
• History of depression preceding a concussion
• History of developmental delays or Attention Deficit Hyperactivity Disorder (ADHD)
• History of post-traumatic seizures
• History of complex spine and/or skull trauma

Dietary Supplement: Nicotinamide Riboside, Other: Matching placebo

Concussion, Mild

Brain Nicotinamide Adenine Dinucleotide (NAD+), Adenosine Triphosphate (ATP) Depletion, Polyadenosine Diphosphate-Ribosepolymerase (PARP) Activation

Sarah Bedell -
Xiao-Hong Zhu
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