This phase III trial compares rose geranium in sesame oil nasal spray to isotonic nasal saline in improving symptoms of nasal vestibulitis in cancer patients receiving chemotherapy. Nasal (nose) symptoms (dryness, discomfort, bleeding, scabbing or sores) due to inflammation, termed nasal vestibulitis, is reported as a side effect of cancer-directed therapy. Rose geranium in sesame oil nasal spray may work better than isotonic nasal saline in improving symptoms of nasal vestibulitis.

Sugars, which are present naturally in some tobacco types and are also added to cigarette tobacco filler as additives, are may contribute to the harmful properties of cigarettes in three critical ways: by enhancing smoke palatability and appeal and, as precursors to aldehydes and other constituents in the smoke, by increasing smoke toxicity and carcinogenicity and potentially addictiveness. The overall goal of our research is to provide the U.S. FDA with the scientific basis to determine whether sugars should be added to the list of harmful and potentially harmful constituents (HPHC) list and whether their levels in tobacco products should be regulated. In this particular study, we will investigate the impact of sugar content in cigarette tobacco on cigarette abuse liability and appeal. To achieve this goal, we will conduct a laboratory study in which smokers of cigarettes with medium sugar content will smoke study cigarettes with differing levels of sugars in a laboratory setting. To prepare cigarettes, we will add a mixture of sucrose, glucose, and fructose to cigarettes that have low sugar content to match median and highest levels of sugars found in other commercial brands. Subjective and behavioral measures assessing abuse liability, sensory measures, and smoking topography will be compared across cigarettes with low (original), medium, and high sugar content.

In this study we want to find out more about weight loss and how diet and medications can affect weight loss. This study will last for up to 58 weeks. There are two phases to the study: - A weight loss phase with prescribe meals that lasts 6 weeks. - A study medication/placebo phase that lasts up 52 weeks. You will not know if you are receiving the medication or the placebo.

This is a within-subject, multi-session behavioral study that will examine the roles of nicotine concentration and e-liquid flavors on subjective and behavioral measures of electronic cigarette abuse potential for young adult smokers.

We are doing the RARE study to learn more about Cystic Fibrosis (CF). CF is caused by mutations in a gene that produces a protein called the cystic fibrosis transmembrane conductance regulator (CFTR). In people with CF, the CFTR does not function correctly. Medications are being developed to help the CFTR function better, but those medications mostly benefit people with common CFTR mutations. There are more than 1,900 mutations of the CF gene. Some of these mutations are rare and found only in a few people. The goal of this research study is to collect specimens (blood, nasal cells, rectal cells) from people with rare CFTR mutations. Another purpose of this study is to create induced pluripotent stem cells or iPS cells. “Pluripotent” stem cells are cells that can be changed into almost any cell type of the body (such as lung or intestine). They can be kept alive and stored indefinitely. There are different kinds of pluripotent stem cells. Inducted pluripotent stem cells can be created from many different kinds of specimens (such as blood, nasal cells, rectal cells). This is different from embryonic stem cells, which can only be derived from embryos. The specimens collected during this study and iPS cells created from them will be stored for use in future research to learn more about CF and study the effect of new medications. This could identify new medications that may help people with rare CFTR mutations.

Understand the extent of proprioceptive impairments in the upper and lower limbs in individuals with stroke by evaluating ankle and wrist joint proprioceptive acuity using the ankle and wrist robotic devices

This study is a prospective, randomized, multi-center, global investigation to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to oral anticoagulation in patients after AF ablation.

Subject-Collected Dried Blood Spot CMV Testing to Optimize Preemptive Therapy Late After Allogeneic HCT

This study pursues the question of whether deep engagement in creative activities may benefit adolescents with depression symptoms by introducing a more flexible way of thinking, helping adolescents recognize and foster their own creative talents, and (ultimately) developing more positive views of themselves and their futures.

This study will measure the relationship between voice-related quality of life and psychosocial distress in transgender and gender diverse patients with a voice concern. Participants participate in an semi-structured interview to characterize their voice-related experiences and the role of voice-related perceived control related to their voice concerns.

We have started this program from other existing projects focused on families. The main difference is that we would like to deliver a program that helps refugee families that have come to the United States. We know that transition can be difficult for parents and teenage children. Our goal is to help families develop tools and skills to work through family problems. Based on your feedback we will make small changes to the program sot that it meets the needs of refugee families. Once we have done this, we will deliver the program to larger numbers of refugee families living in Minnesota. Please note the changed title to match the K23 submission title. I updated the funding with the K23 SPA CON number as well as a CTSI pilot grant that started in March and is supporting project activities.

The primary objective is to determine the incidence of grade II-IV acute graft versus host disease (GVHD) by Day 100 using an alpha/beta T cell depleted peripheral blood stem cells (PBSC) and without routine GVHD prophylaxis.

Among people with peripheral artery disease (PAD) age 55 and older, we will test the hypothesis that PAD participants randomized to cocoa flavanols will have greater improvement or less decline in six-minute walk distance at six-month follow-up, compared to those randomized to placebo. We will randomize 190 participants (32 in Minnesota) with PAD age 55 and older to one of two groups for six months: cocoa flavanols vs placebo. Our primary outcome is change in six-minute walk distance at six-month follow-up. Secondary outcomes are six-month change in maximal treadmill walking distance, Actigraph-measured physical activity, whole body oxygen consumption, measures of nitric oxide (brachial artery flow-mediated dilation (FMD)), calf muscle endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS, calf muscle perfusion (measured by magnetic resonance imaging (MRI)) and calf muscle characteristics (measured by calf muscle biopsy). To achieve our specific aims, we will randomize 190 participants age 55 and older with PAD to one of two groups: cocoa flavanols vs placebo. Participants will be followed for seven months.

This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglio-neuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

STABILITY 2 is a 21-site multicenter, international, randomized clinical trial that will randomly assign 1236 individuals with an anterior cruciate ligament (ACL) deficient knee who are at high risk of re-injury to anatomic anterior cruciate ligament reconstruction (ACLR) using bone patellar tendon bone (BPTB) or quadriceps tendon (QT) autograft with or without a lateral extra-articular tenodesis (LET).

3.1 Primary Endpoint/Event/Outcome: To determine if stimulated T cell production of IFN-γ and stimulated monocyte production of TNFα as quantitated by ELISpot, better predicts important clinical metrics of impaired immunity in patients with sepsis than commonly used protein and nucleic acid measures of immune endotype.

Study is to investigate the relationship between Bispectral Index (BIS) values including EEG profile and anesthetic agents in the pediatric population.