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A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Study to Investigate the Safety and Efficacy of Oral Brepocitinib in Adults with Cutaneous or Oral Lichen Planus or Lichen Planopilaris
Status: Recruiting
The purpose of this study is to learn more about the use of an investigational medicine, called brepocitinib, for the treatment of lichen planopilaris (LPP). Brepocitinib (the “study drug”) is designed to decrease inflammation. The study will look at how safe and effective brepocitinib is and will monitor long-term safety when it is taken for up to 52 weeks. The study drug will be compared to a placebo which is a tablet that looks exactly like the study drug but does not contain any active ingredient.
Sex: Male or Female
Age Group: 18 years and over
Inclusion Criteria:
• diagnosed with lichen planopilaris (LPP)
Exclusion Criteria:
• have a history of certain blood or lymphatic system cancers, currently have cancer, or have been treated for most cancers within the past 5 years
• have a high risk of blood clots, heart disease, stroke, or shingles
Interventions:
Drug: Oral Brepocitinib, Drug: Placebo
Conditions:
Dermatology (Skin, Hair & Nails)
Keywords:
Clinics and Surgery Center (CSC), lichen planopilaris, LPP
Study Contact: Jaime Nugent - speck007@umn.edu
Principal Investigator: Maria Hordinsky
Phase: PHASE2
IRB Number: STUDY00027335
See this study on ClinicalTrials.gov