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Altered cortical representation of paretic leg muscles in individuals with stroke: a TMS-based motor mapping study
Status: Recruiting
This research study is aimed at finding the changes in brain activity of people who have experienced a stroke and how it may affect their movement coordination during walking. Participants will be asked to walk on a treadmill at a comfortable speed while their movement pattern will be measured. Participants will also undergo magnetic resonance imaging (MRI) scan and assessment of the brain activity using Transcranial magnetic stimulation (TMS) which is a non-invasive brain stimulation method often used to stimulate nerve cells in the brain and assess connectivity between the brain and individual muscles.
Sex: Male or Female
Age Group: 18 years and over
Inclusion Criteria:
• 18-85 years of age
• have either ischemic or hemorrhagic stroke at least six months ago
• had a single stroke or multiple strokes on the same side of the brain
• have residual paresis in the lower extremity
• can walk at least 10 feet with or without assistive device
• fluent in English
Exclusion Criteria:
• history of seizures
• take medications that could lower seizure thresholds
• history of brain injury or other CNS disease (with exception of stroke
• have a pacemaker or metal or electric implant in the head, neck, or chest area
• have non-MR compatible implants
Conditions:
Brain & Nervous System
Keywords:
Stroke
Study Contact: Mia Kellman - kellm003@umn.edu
Principal Investigator: Jacqueline Palmer
IRB Number: STUDY00024574