Treatment of Refractory Nausea


We are studying different drugs for the treatment of nausea and vomiting that is caused by chemotherapy treatment of people who have breast cancer.

I'm interested

18 years and over
This study is NOT accepting healthy volunteers
Inclusion Criteria:

• diagnosis of breast cancer and not yet started chemotherapy
• scheduled to receive a single-day chemotherapy regimen that contains doxorubicin and/or cyclophosphamide and/or carboplatin
• scheduled to receive an antiemetic regimen that does not contain Akynzeo
Exclusion Criteria:

• clinical evidence of current or impending bowel obstruction
• history of central nervous system disease (e.g., brain metastases or a seizure disorder)
• uncontrolled diabetes mellitus or uncontrolled hyperglycemia
• long term treatment (> 5 days within the past 30 days) with an antipsychotic agent such as risperidone, quetiapine, clozapine, a phenothiazine, or a butyrophenone within 30 days before enrollment or plans for such treatment during the study period
• taking benzodiazepines regularly (> 5 days within the past 30 days); (PRN) use (=< 5 days) for the short-term relief of the symptoms of anxiety, anxiety associated with depressive symptoms

Drug: Dexamethasone, Other: Laboratory Biomarker Analysis, Drug: Netupitant/Palonosetron Hydrochloride, Drug: Olanzapine, Other: Placebo, Drug: Prochlorperazine, Other: Quality-of-Life Assessment


Breast Cancer, Breast Cancer, Chemotherapy, Nausea

Kristen Nelson -
Kiran Lassi
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