StudyFinder
ITCC-101/APAL2020D - A randomized phase 3 trial of fludarabine/cytarabine/gemtuzumab ozogamicin with or without venetoclax in children with relapsed AML (A subtrial of the PedAL/EuPAL relapsed acute leukemia master protocol)
Status: Recruiting
A study to evaluate if the randomized addition of venetoclax to a chemotherapy backbone (fludarabine/cytarabine/gemtuzumab ozogamicin [GO]) improves survival of children/adolescents/young adults with acute myeloid leukemia (AML) in 1st relapse who are unable to receive additional anthracyclines, or in 2nd relapse.
Sex: Male or Female
Age Group: Not specified
Inclusion Criteria:
• participants must be at least 29 days of age and less than 21 years of age at enrollment
• participants must have enrolled on APAL2020SC, NCT Number: NCT04726241
• children, adolescents, and young adults with acute myeloid leukemia without FLT3/internal tandem duplication (ITD) mutation
• second relapse who are sufficiently fit to undergo another round of intensive chemotherapy
• first relapse who per investigator discretion cannot tolerate additional anthracycline containing chemotherapy
• see link to clinicaltrials.gov for complete criteria
Exclusion Criteria:
• participants with Down syndrome
• participants with Acute promyelocytic leukemia (APL) or Juvenile myelomonocytic leukemia (JMML)
• study staff will review additional exclusion criteria
Interventions:
Drug: Azacitidine, Drug: Cytarabine, Drug: Fludarabine, Drug: Gemtuzumab Ozogamicin, Drug: Venetoclax
Conditions:
Cancer, Cancer
Keywords:
Acute Myeloid Leukemia, AML
Study Contact: Allison Fullenkamp - fulle631@umn.edu
Principal Investigator: Peter Gordon
Phase: PHASE3
IRB Number: SITE00001628
See this study on ClinicalTrials.gov