Our Center will focus on the unifying hypothesis that processes underlying state representation dysfunction are relevant to psychosis, providing a window into pathophysiologic heterogeneity and precision treatment. Our Center will study three species (nonhuman primates, mice, and humans) using eight methodologies (genetic manipulations, slice physiology, ensemble recordings, LFP, behavior, EEG, fMRI, cognitive training). We will use a central computational perspective to translate and integrate across species and methodologies: Changes in neural information processing that affect parameters underlying attractor dynamics and influence state representation processes. Such changes create observable effects in behavior and neurophysiology, which we will study through the lens of attractor network models to inform our understanding of pathophysiologic heterogeneity, clinical trajectories, and precision treatment.
English proficiency, as determined by staff observation and participant self-report
Estimated IQ at or above 70, as estimated by the cognitive assessments
Additional Inclusion Criteria for Early Psychosis Participants:
Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis, with onset of psychotic symptoms within the previous 5 years
Achieved clinical stability, defined as outpatient status for at least one month prior to study participation plus clinically stable doses of psychiatry medications for at least one month prior to study participation
Exclusion Criteria:
Unable or unwilling to provide informed consent
The participant is unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in the research study
Participant is pregnant
Participant is illiterate
Cannot pass the CMRR Subject Safety Screen due to MRI contraindications
Presence of a major neurological disorder
Previous clinically significant head injury or prolonged unconsciousness, as determined by the PI/Co-Is
Meets criteria for substance or alcohol dependence within 3 months of enrollment
The presence of any major medical condition that, in the opinion of the PI/Co-Is, would impede participation in the study or would put the participant at additional risk by participating
Additional Exclusion Criteria for Early Psychosis Participants:
Has participated in significant formal cognitive training programs, as determined by the PI/Co-Is
Meets criteria for clinical risk of suicidal behavior, as defined by:
Clinician judgement
A suicide attempt within 6 months of enrollment
Active suicidal ideation at screening or baseline, as indicated by the C-SSRS
Previous intent to act on suicidal ideation with a specific plan and/or preparatory acts within 6 months of enrollment, as indicated by the C-SSRS
Additional Exclusion Criteria for Control Participants:
Meets DSM-5 criteria for psychotic, bipolar, or autism spectrum disorder
Has a family history (1st degree relative) of psychotic, bipolar, or autism spectrum disorder
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