StudyFinder
A non-randomized prospective clinical trial comparing the non-inferiority of salpingectomy to salpingo-oophorectomy to reduce the risk of ovarian cancer among BRCA1 carriers (SOROCk)
Recruiting
The purpose of the study is to compare two surgical procedures and their ability to decrease the risk of developing ovarian cancer for pre-menopausal women with BRCA1 mutations.
Female
35 years to 50 years old
Inclusion Criteria:
• 35 to 50 years old
• women with a BRCA1 mutation
• undergoing risk-reducing salpingo-oophorectomy or who have declined or elected to defer BSO
• may be premenopausal or menopausal
Exclusion Criteria:
• history of any prior cancer who have received chemotherapy within the past 30 days or radiotherapy to abdomen or pelvis at any prior time
• women with abnormal screening tests (TVUS, CA-125) suspicious for gross cancer within the past 180 days
• additional criteria apply (study staff will review)
Procedure: Bilateral Salpingectomy, Procedure: Bilateral Salpingectomy with Oophorectomy, Procedure: Biospecimen Collection, Other: Quality-of-Life Assessment, Other: Questionnaire Administration, Procedure: Transvaginal Ultrasound, Procedure: Ultrasound Imaging
Cancer, Women's Health
Clinics and Surgery Center (CSC), BRCA1, Ovarian Cancer