Search Results
D2D-Improving Invasive Species Identification through an Interactive Digital Guide for Non-Experts
Can you tell which plants belong in Minnesota and which do not? We are studying what visual designs can help Minnesotans learn to identify invasive plants in our state. So visit our booth at the Minnesota State Fair Research Building to try our new interactive guide and share your feedback.
• ages 18 years or older
• resident of Minnesota
Neuroplasticity in REM Sleep Behavior Disorder
REM sleep behavior disorder (RBD) is a condition in which people physically act out their dreams while sleeping. Some people with RBD may later develop neurological conditions such as Parkinson's disease or related disorders. This study will examine changes in the brain over a two-year period using advanced brain imaging (7T MRI) and other neurological tests. Researchers will compare people with RBD to people without the disorder to better understand how the brain changes over time and identify potential early signs of neurological disease.
• aged 21-75
• diagnosed with REM Sleep Behavior Disorder (RBD)
Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM sleep Behavior Disorder
This research is being completed to examine the cells, brain imaging, and speech in individuals with REM Sleep Behavior Disorder who are taking serotonergic medications such as Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine and Sertraline. The purpose of examining these is to try and see if we can predict signs of Dementia with Lewy bodies (a progressive form of dementia with an increase in decline of thinking, reasoning, and other functions). This may benefit others by enabling us to diagnose Dementia with Lewy Bodies sooner rather than later.
• 18 to 75 years old
• diagnosis of polysomnogram-confirmed RBD (e.g. narcolepsy) with history of dream enactment or clear dream enactment visualized on video from polysomnogram
• dream enactment began shortly after (less than 2 months) starting a serotonergic antidepressant medication
• for Healthy Volunteers: on serotonergic medication for at least 6 months without history of dream enactment
• the following serotonergic medications are included for both groups: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, and Sertraline
• Parkinsons disease, dementia with Lewy bodies, Multiple System Atrophy, Pure Autonomic Failure, Alzheimers disease, other diagnosed neurodegenerative disorder, or other known cause of RBD (e.g. narcolepsy)
• untreated obstructive sleep apnea, obesity hypoventilation, central sleep apnea or other sleep disordered breathing
• unable to have a MRI scan
• women who are pregnant
• for Healthy Volunteers: same exclusion criteria as those with 5-HT RBD group, plus history of dream enactment, or increased REM motor tone
COgnitive STrategies in Early Psychosis 1 (COSTEP 1)
This study is about decision making in psychosis spectrum disorders, like schizophrenia. We will study how a single dose of a study agent called modafinil changes how people complete computer tasks and changes how the brain functions. We hope to improve our understanding of psychosis to help people in the future.
• 18 to 35 years old
• speak English as primary language
• major medical diagnosis such as neurological disorder, kidney, heart, liver disease
• people who are pregnant, breastfeeding, or planning to become pregnant
• have a diagnosis or immediate family history of a psychotic, bipolar, or autism spectrum disorder
• study staff will review additional criteria
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
This study includes healthy adults between the ages of 21-70 who either use or do not cannabidiol (CBD) regularly. The purpose of this study is to learn about how CBD users and nonusers respond to stress. Participants must be willing to attend one in-person visit at the University of Minnesota Duluth campus
• 21 to 70 years old
• generally healthy
• use CBD regularly or do not use CBD
• willing to attend one in-person visit at the University of Minnesota campus
• current, unstable physical or mental health condition
• women who are currently pregnant
• current use of illicit substances (other than cannabis)
D2D: Tyrannosaurus Flex: Finding the "Fair-ly Normal" Grip
How strong is your squeeze? We’re inviting kids aged 2-12 to test their grip and help us establish new standards for hand strength. Your contribution allows our team to create more inclusive, accurately calibrated technology that works for everybody. Stop by the Minnesota State Fair Research Building for a Tyrannosaurus Flex to help us find the Fair-ly Normal Grip and help us build the future of interactive play!
• ages 2-12 years old
• musculoskeletal, neurological, or neuromuscular conditions affecting upper limb strength or function
• diagnosis of a systemic condition affecting the musculoskeletal or nervous system
• previous hand, wrist, or upper limb surgery
• history of hand, wrist, or upper limb trauma
• current pain in either hand or upper limb
D2D From Pamphlets to Videos: Optimizing Patient Education on Kidney Stone Prevention
How do you learn best, by watching or reading? With the rise of short videos on apps like TikTok, we’re studying how people prefer to learn about health. Participants at the Minnesota State Fair Research Building will learn about kidney stones either through a quick video or a simple pamphlet, like one you might get at a doctor’s office. Then, they’ll take a brief quiz and share their preferences. This study helps us understand the best ways to share health information, so patients feel more confident and empowered in their care.
• ages 18 years or older
D2D: studying planning by playing Tetris
Play Tetris while researchers at the Minnesota State Fair Research Building measure your brain activity to better understand how the brain works during gameplay.
• ages 14-80 years
• have had a seizure
• family history of epilepsy
Prevalence of Hidradenitis Suppurativa in the Minnesota population
Help researchers learn how common hidradenitis suppurativa (HS), a chronic skin condition, is among adults by answering a few health questions and having your skin checked for signs of HS at the Minnesota State Fair Research Building.
• pregnant women
Blue-Ribbon Bladder Study: Understanding How Women Care for their Bladders
The Blue Ribbon Bladder Study is a project just for women. We want to learn more about how women manage everyday bladder issues and use what we learn to find better ways to support bladder health. Visit us at the Minnesota State Fair Research Building to learn more and share your experience! Help us make bladder health an easier part of everyday self-care.
• women ages 18 years or older
• have a Urostomy
• regularly use urinary catheters
Determining Normative Hand Measurements to Optimize Hand Reconstruction Aesthetic Outcomes
Help researchers at the Minnesota State Fair Research Building learn how people naturally hold a pen while writing. This information may improve therapies that support handwriting skills.
• ages 5 years and older
D2D "Fair" Game: Generational Factors in Assessing Cognition
The UMN Neuropsychology team invites you to the Minnesota State Fair Research Building to complete a brief health survey and a couple of quick cognitive tests to help us learn how different generations, from Silent and Boomers to Millennials and Gen Z, complete two executive functioning tasks.
• ages 18 years or older
• history of certain serious neurological conditions, such as stroke, multiple sclerosis, severe brain injury, or dementia
• severe heart disease or other serious organ-related conditions
• currently receiving chemotherapy or radiation treatment for cancer
• certain severe mental health conditions, such as schizophrenia or bipolar disorder
D2D: Spit it Out!
Share what you know and think about dental therapists and oral health at the Minnesota State Fair Research Building. Your feedback will help improve communication and access to dental care.
• ages 18 years or older
• current Minnesota residents
RELATE Study - How Partners Stay Connected Under Stress. Communication and Dyadic Coping Behaviors as Mechanisms Linking Emotion Regulation and Sexual Health Outcomes While Facing Diverse Stressors
How does your relationship handle stress? Complete a brief survey at the Minnesota State Fair Research Building about communication, coping, and connection to help researchers learn what keeps relationships strong.
• ages 18 years or older
• currently in a romantic relationship
D2D Swish for Science
Swab and rinse your mouth to help researchers study the bacteria that affect oral health. Participate in a quick activity at the Minnesota State Fair Research Building and take home a prize!
• adults ages 18+
D2D Great Minnesota Public Opinion Survey 2026
Share your opinions on topics that matter to the University of Minnesota by completing a brief public opinion survey at the Minnesota State Fair Research Building!
D2D - Beyond Closed Doors: A MN public opinion survey about intimate partner violence
Share your thoughts about relationship violence and domestic abuse in this anonymous survey at the Minnesota State Fair Research Building. Your responses will help improve education and prevention efforts across Minnesota.
• age 18 or older
• resident of Minnesota
Registry Study of Childhood Cancer in Minnesota
The aim of this study is to obtain newborn blood spots (NBS) and tumor specimens for children and adolescents diagnosed with malignant neoplasms.
• 0 to 21 years of age
• child diagnosed with any type of tumor or cancer
• born in a state that banks newborn blood spots
• able to understand English or Spanish
• parents or siblings may also contribute specimens
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
We will enroll healthy pregnant women (following enrollment, all subsequent study procedures will be completed postpartum) or postpartum women on hormonal birth control or no hormonal birth control with either a recent history of smoking and a desire to remain abstinent after childbirth, or who are currently smoking and motivated to quit smoking. Participants will be recruited throughout the continental United States (US). Participants living in Minnesota (our clinical site) will receive a 12-week course of exogenous progesterone. Participants will be followed for six months with remote visits, self-administered surveys, and self-collection of dried blood spots to measure hormones and smoking-related biomarkers.
• 18 to 45 years old
• uncomplicated pregnancy at gestational week 30 or beyond, or birth of a child within the past 6 months
• history of ≥ 4 cigarettes per month during the six months prior to pregnancy
• motivation to become and/or stop smoking after delivery
• willing to use birth control for the 12 weeks of the study
• live in the continental US and have a device to connect to the internet for participation
• see link to clinicaltrials.gov for complete inclusion criteria
• current daily use of nicotine replacement therapy or smoking cessation medications, with the exception of e-cigarettes
• major depressive disorder
• current or within the past 3 months treatment for drug or alcohol use
• see link to clinicaltrials.gov for complete exclusion criteria
University of Minnesota Registry for Epilepsy and Seizure Disorder Research
The University of Minnesota Registry for Epilepsy and Seizure Disorder Research (UM-REaSD) connects people interested in epilepsy and seizure disorder research with University of Minnesota researchers. By joining the registry, you can share your contact information and basic health information so researchers can contact you about future studies you may be eligible to participate in.
• 18 years of age or older
• interested in participating in epilepsy and seizure disorder research at the University of Minnesota
Pathogen Genomics Center of Excellence: Prospective Surveillance of Respiratory Pathogens and Antimicrobial Resistance in Diverse Regional Populations (MINNE-LOVE-2)
Respiratory illnesses, including ear and sinus infections, colds, and pneumonias, are among the most common infectious diseases affecting Minnesotans across their lifespan. These diseases can be caused by many different types of microbes—bacteria, viruses and fungi—and different types of microbes may require different kinds of treatment. This research is being done to learn more about the specific types of microbes that cause respiratory infections in children and adults across the state of Minnesota over time. Antimicrobial resistance happens when microbes develop the ability to defeat the drugs designed to kill them. Through this study, we will learn which types of genes are carried by microbes living in the respiratory tract by collecting and analyzing nasal and oral specimen.
• age at least 18 years and able to provide informed consent AND willing and able to collect nasal swabs and complete symptom questionnaires with symptomatic respiratory illness Or
• age less than 18 years within the same household of at least 1 adult participant in study AND parent/guardian available to provide informed consent AND self or parent/guardian willing and able to collect nasal swabs and complete symptom questionnaires with symptomatic respiratory illness
• presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the participant or the quality of the data (e.g., parent not able to answer the questionnaire because of a psychological condition or an anxiety disorder that is severe)
• routine mucosal specimen collection is not medically advised (such as severe immunocompromising condition, bleeding disorder)
Influence of functional hypothalamic amenorrhea on autonomic blood pressure regulation in female endurance athletes
This study is being done to learn more about how hormone changes related to menstrual cycle disruption and underfueling in highly trained endurance athletes may affect blood pressure regulation, blood vessel function, and cardiovascular health. Researchers will measure heart rate, blood pressure, blood vessel function, and nervous system activity in endurance athletes to better understand how these factors differ between athletes.
• females ages 18–35
• endurance athletes who regularly participate in sports such as running, cycling, swimming, skiing, rowing, or multisport activities
• current injury limiting training participation
• pregnant or breastfeeding
• use of depo provera, nexplanon implants, or progestin-only oral contraceptives
• diabetes or significant heart, lung, neurologic, metabolic, or endocrine conditions
• nicotine/tobacco use in the last six months
• current use of heart or blood pressure medications
Assessing Changes in Knowledge and Attitudes Toward Transcranial Magnetic Stimulation (TMS) After a Demonstration-Based Intervention
The purpose of this study is to learn whether watching a short educational video changes what people know and think about transcranial magnetic stimulation (TMS), a non-medication treatment for depression that uses magnetic pulses. Researchers will also compare different video styles to determine which is most effective at increasing knowledge and improving attitudes about TMS.
• ages 18+
Project GRaNoLA (Gender Role and Norm: Learning and Accepting)
This study is exploring how children understand and form opinions about differences in how adults express their gender through appearance, speech, and behavior. Researchers are interested in learning how children think about gender expression and whether their perceptions vary based on different aspects of how gender is represented.
• children between 5 and 10 years old
• able to understand and speak English
• history of developmental disorders, language delays/disorders, or vision or hearing impairments
Kinematic signatures of postural instability and gait in Parkinson Disease
The purpose of this research is to better understand balance and walking in patients with Parkinson’s Disease. This research study uses small wearable devices that attach to clothing and can measure the body’s location while performing walking and balance tests.
• People diagnosed with Parkinson's disease, with or without implanted Deep Brain Stimulator (DBS). May be at any age of disease progression.
• Healthy adults of similar age to participants who have Parkinson's Disease and are enrolled in the study.
Influence of menopause and sex hormone deficiency on autonomic and vascular determinants of blood pressure
This study is being done to learn more about how menopause influences the autonomic (fight or flight) and vascular (blood vessels) function in midlife females. To understand how blood pressure is regulated, we will make several measurements, including heart rate, blood pressure, sympathetic function (also known as the fight or flight system), and how blood vessels regulate blood flow.
• women who are 45-55 years old
• premenopausal
• currently have a normal menstrual cycle
• not planning to become pregnant for the duration of participation in the study
• able to read, write & speak English
• diabetes
• pregnant or breastfeeding
• cardiac or lung disorders
• severe obesity (body mass index [BMI] ≥ 40 kg/m 2 )
• hypertension
• obstructive sleep apnea
• current use of heart or blood pressure medications or antidepressants
• history of treatment with chemotherapy/radiation
• coagulopathy disorders and/or use of anticoagulant medications
• current use of hormonal contraceptives
• nicotine/tobacco use in the last six months
• current alcohol abuse
Emotion Regulation Knowledge Study
The purpose of this study is to develop and evaluate a storybook-based tool that measures how children ages 4 and older understand and manage their emotions. Researchers will examine how children choose different emotion regulation strategies in a variety of situations, such as interactions with family, friends, or when alone, and how these skills relate to children's social and emotional development.
• children ages 4–12 years
• parent or legal guardian able to provide informed consent
• child and parent willing to participate in a single research visit involving an iPad-based storybook activity and a brief parent survey
Pediatric 3D Scanned Images Database
The purpose of this study is to collect 3D measurements of children's faces, heads, hands, and feet using a safe, non-invasive 3D scanner. These measurements will help researchers design and improve medical devices that better fit children's unique needs.
• infants, children, and adolescents from 35 weeks gestational age to under 18 years old who are receiving care in the hospital or participating at the State Fair Research Building at the Minnesota State Fair
• individuals who are too medically unstable to participate or require a breathing tube through the mouth
The Lung Cell Study (TLC)
The purpose of our research study is to increase our understanding on the human lung immune response to infection. We aim to use this knowledge to develop novel approaches on the prevention and treatment of lung infections. To accomplish this, we plan to obtain cells from the airways and blood of healthy volunteers to perform immune experiments.
• healthy volunteers without systemic or respiratory disease
• non-smokers or former smokers who quit more than 6 months ago (including marijuana)
• ages 18-50
• preferred but not required: have lived in countries in Africa, Latino America or South East Asia
• preferred but not required: history of positive tuberculosis (TB) skin or blood test
• recent illness, bleeding disorders, or a history of heart, lung, or systemic disease
• weakened immune system or use of immunosuppressant medication
• use of inhaled substances in the past six months or history of heavy smoking
• allergy or prior adverse reaction to lidocaine, midazolam, or fentanyl
• pregnancy
Characterization of spleen motion and anatomy using imaging and sensors
This research is being performed to examine how the spleen moves during breathing in various body positions and breathing conditions. Physical measurements of the participant's body will be recorded (weight, height, and body dimensions) and then noninvasive recordings of the spleen and breathing patterns will be recorded. The spleen motion will be measured using standard abdominal ultrasound imaging, and breathing will be measured with accelerometers (small devices about the size of a quarter that measure the movement of the chest during breathing).
• at least 18 years old
• individuals who have had a splenectomy
• people with breathing difficulties and/or individuals for whom short breath holds and modification of breathing patterns is difficult or uncomfortable
• unable to maintain five body positions: sitting, sitting with a 45 degree recline, laying on back (supine), laying on right side, and laying face down (prone) comfortably and independently
• unable to speak and read English