StudyFinder
Vibrotactile stimulation of the larynx to treat unexplained chronic cough
Recruiting
This is a study of adults with unexplained chronic cough between 18-80 years old. This study is trying to determine whether a noninvasive vibrotactile stimulation device can help reduce cough symptoms.
All
18 Years and over
Inclusion Criteria:
- Adults aged 18-80
- >8 weeks of non-productive cough
- Cough visual analogue scale (VAS): Rating of 40 or greater on a 0-100 cough severity scale
- CXR or chest CT negative (collected as part of routine clinical care); no time limit on imaging (if available)
- Clinical impression that untreated or inadequately treated gastroesophageal, pulmonary, and/or sinonasal source is not primary cough etiology
- Ability to provide informed consent and independently complete questionnaires
- Ability to read and speak English
Exclusion Criteria:
- Current or recent (quit < 3 months ago) smoking
- Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
- History of known or suspected aspiration pneumonia
- Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA)
- Untreated carotid disease
- Electronic implants (e.g., pacemaker)
- Specific medication use conditions, including:
- Taking ACE-inhibitors
- Around the clock use of benzodiazepines
- Anticipate new medications targeting cough during the period of the study
- If on neuromodulators and/or opioids, anticipate change in dose during the period of the study
- Currently doing speech therapy for cough
- BMI > 30 (for transmission of VTS through soft tissue)
- Contraindications to safe VTS device use, including:
- Allergy to adhesives
- Unable to manipulate device
- Recent intubation/neck surgery (within 8 weeks)
- Drug/alcohol dependency or abuse
- Pregnant
- No regular access to wifi internetDevice: Vibrotactile Stimulation
Breathing, Lung & Sleep Health, Ear, Nose & Throat, Cough
Chronic cough, Clinics and Surgery Center (CSC), chronic cough, cough, larynx, vibrotactile stimulation
Anna Sombrio - sombr004@umn.edu
Stephanie Misono
N/A
STUDY00012174
NCT05273190
See this study on ClinicalTrials.gov