Expansion Cohort Study of Disulfiram and Chemotherapy in Pancreas Cancer Patients


Disulfiram is a potential inhibitor of muscle degradation and may reduce tumor induced muscle wasting. Emerging research also suggests it might have anti-cancer effects. This study examines whether targeting muscle loss with Disulfiram will reverse disability and eventually improve survival in patients with incurable pancreatic cancer. It tests the safety, tolerability and potential benefit of disulfiram (Antabuse®) in combination with chemotherapy

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This study is NOT accepting healthy volunteers

Stage IV Pancreatic Cancer AJCC v8, Metastatic Pancreatic Adenocarcinoma, Refractory Malignant Solid Neoplasm

Patricia Beckmann -
Aminah Jatoi
Phase II
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